Date: 09/30/2024

Journal of Investigative Dermatology

by Brian S. Kim and Daniel Yassky

Unbiased scRNA-seq, functional assays, and clinical trials have revealed that itch is a highly evolutionarily conserved sensation with great potential for translational discovery. Thus, mouse models of both acute and chronic itch can be and have been used to preclinically define, validate, and predict therapeutic targets. However, misconceptions about the value of mouse models and how they can be deployed often result in confusion.

https://www.sciencedirect.com/science/article/abs/pii/S0022202X24020876?dgcid=author