Functional consequences of keratin isoform switching during epidermal differentiation (2023)
Benjamin Nanes, MD, PhD
Instructor of Dermatology, UT Southwestern Medical Center, Dallas, TX
Award: $35,000
In epidermolytic ichthyosis, mutations affecting keratin 1 (K1) or keratin (K10) disrupt the keratin mechanical scaffold. Understanding K1/10-specific functions that may not be rescued by other keratin isoforms expressed in epidermis is critical for many potential treatment strategies. This proposal aims to overcome our gaps in understanding if and how these keratins associate with signaling networks to modulate epidermal differentiation and barrier formation, which may reveal entirely novel therapeutic approaches for the wide variety of skin diseases where epidermal architecture is disordered.
Read Dr. Nanes' 6 month project update here.
Researchers interested in funding Through FIRST'S Research Grant Program
